Supplement Facts | Canada
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Supplement Facts

Insulin is essential for maintaining healthy blood sugar (glucose) levels. Non-prescription AXULIN® supports healthy glucose metabolism by helping your body metabolize both carbohydrates and fats.1,2  Here’s how3-5:

Green leaf with drop of water

  • Insulin signaling is mainly controlled by a protein called IRS-2
  • IRS-2 is activated when insulin binds to an insulin receptor on a cell’s surface
  • This activation stimulates glucose uptake from the blood

Laboratory and clinical studies have shown that AXULIN provides support for the body's glucose regulating process by targeting the same pathway that insulin uses to control blood sugar.1-5

Axulin Ingredients

Along with being a staple of our daily diets, herbs and vegetables have been found to have additional benefits that can serve as a healthy approach to managing many ailments—including diabetes.6-13  Plant-based AXULIN is formulated to maintain healthy blood sugar levels and metabolize carbohydrates and fats. It also provides nutritional support that may benefit people with type 2 diabetes, insulin resistance, metabolic syndrome or pre-diabetes.1-3,5,6

The ingredients in AXULIN were specifically selected from over 100,000 compounds, including edible plant species.1,17 Through testing, Housey scientists discovered that certain species of edible plants contain active ingredients that stimulate insulin signaling in human cells. These compounds were initially discovered to  be present in trace amounts in these plants.17

After years of experimental investigation, Housey scientists developed methods of identifying, concentrating, purifying and activating these compounds to provide highly active plant-derived compounds in a convenient tablet form.

To learn more about these edible plants, click on the (+) symbol next to each one below.

Each Tablet CoNTAINS:

Medicinal Ingredients

For people with Type 2 Diabetes, studies show that high-fiber diets can improve blood sugar, lipids, and insulin levels.14  Escarole is a leafy green often used in soups and salads that is a good source of a wide range of dietary fiber, vitamins and minerals. It’s low in calories and has zero fat. Escarole is also a rich source of provitamin A, which can help improve eyesight and vision problems, and antioxidants, which may protect your cells against chronic inflammation. It also offers vitamin K to support stronger bones and reduce the risk of heart disease.15

Lactuca sativa is a form of leafy green lettuce that has been underestimated for its nutritional value. It is low in calories, fat, and sodium, and is a good source of fiber, iron, copper, folate, and vitamins A and C. In studies, bioactive compounds in Lactuca sativa have been shown to reduce inflammation, lower cholesterol, and support anti-diabetic activities. Vitamin A is important for vision, reproduction, embryogenic development, and immune function.  The antioxidant beta-carotene helps lower risk of chronic disease, while zinc is essential for basic cellular function.16

Chromium is a mineral in the body that enhances the action of insulin and appears to be directly involved in metabolizing carbohydrates, fats and proteins.  Meat, whole-grain products, and some fruits, vegetables and spices are good sources of chromium, but most foods offer only small amounts.20

Tarragon is a well-known herb used both for food preparation and healing purposes.  Tarragon is used as a natural source to help regulate the immune system by reducing inflammation and increasing anti-inflammatory properties.18 It is also believed to be an effective therapy for neuropathic pain.19

Non-Medicinal Ingredients

Non-medicinal (inactive) ingredients provide natural health products with properties such as binding and absorption of the product.21 In AXULIN, these ingredients include Dicalcium phosphate, microcrystalline cellulose, silicon dioxide, hydroxypropyl cellulose, stearic acid, croscarmellose sodium, magnesium stearate.

How to Take Axulin

Serving Size: 1 Tablet (980 mg of Active Ingredient)

Quantity: 60 Tablets

Recommended Dose

Adults : Take 1-2 tablets with at least 120 ml (4 fl. oz) of water in the morning and evening, preferably 30-60 minutes before meals, or as directed by your doctor.

Cautions & Warnings

AXULIN is intended for use by adults only. Do not take AXULIN if you are under 19 years of age. Do not use if you are pregnant or breastfeeding. If you have diabetes, consult your physician before using this product. Keep out of reach of children. Do not use if seal is broken.

AXULIN has been approved by the Canadian Government (Health Canada), and has been issued the following Natural Product Number (NPN): 80050544.

References
  1. Data on file. Housey Healthcare ULC. 2019.
  2. https://health-products.canada.ca/lnhpd-bdpsnh/info.do?licence=80050544
  3. https://clinicaltrials.gov/ct2/show/NCT03135015?term=axulin&draw=2&rank=1
  4. White, M. et al. Mechanism of Insulin Action, Textbook of Diabetes, 2017
  5. DeGroot, L. et al. Endocrinology: Adult & Pediatric. 2016; Chapter 33
  6. Joshua ZP, Timothy AG, Suleiman MM. The effect of cooking time on the vitamin C, dietary fiber and minerals compositions of some local vegetables. Science World Journal. 2012;7(1):29-30
  7. Saqier, Bao S, Han S, Wuliji A. Effects of agriophyllum squarrosum extracts on glucose metabolism in KKAy mice and the associated underlying mechanisms. J Ethnopharmacol. 2019;241:112009
  8. Mazibuko-Mbeje SE, Dludla PV, Roux C, Johnson R, Ghoor S, Joubert E, Louw J, Opoku AR, Muller CJF. Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways.  Int J Mol Sci. 2019;20(3):633
  9. Lee D, Lee DH, Choi S, Lee JS, Jang DS, Kang KS. Identification and Isolation of Active Compounds from Astragalus membranaceusthat Improve Insulin Secretion by Regulating Pancreatic β-Cell Metabolism. Biomolecules. 2019;9(10):618
  10. Nambirajan G, Karunanidhi K, Ganesan A, Rajendran R, Kandasamy R, Elangovan A, Thilagar S. Evaluation of antidiabetic activity of bud and flower of Avaram Senna (Cassia auriculata L.) in high fat diet and streptozotocin induced diabetic rats. Biomed Pharmacother. 2018;108:1495-1506.
  11. Wang N, Li T, Han P. The effect of Tianmai Xiaoke Pian on insulin resistance through PI3-K/AKT signal pathway. J Diabetes Res. 2015;2016:9261259.
  12. Hao J, Chen C, Huang K, Huang J, Li J, Liu P, Huang H. Polydatin improves glucose and lipid metabolism in experimental diabetes through activating the Akt signaling pathway. Eur J Pharmacol. 2014;745:152-165.
  13. Qin B, Dawson HD, Schoene NW, Polansky MM, Anderson RA. Cinnamon polyphenols regulate multiple metabolic pathways involved in insulin signaling and intestinal lipoprotein metabolism of small intestinal enterocytes. Nutrition. 2012;28(11-12):1172-9.
  14. 7 Health benefits of endive. Dovemed. Published June 14, 2016. Available at: https://www.dovemed.com/healthy-living/natural-health/7-health-benefits-of-endive/. Accessed November 1, 2019.
  15. What is escarole, and how is it eaten? Healthline. Published January 16, 2020. Available at: https://www.healthline.com/nutrition/what-is-escarole. Accessed January 20, 2020.
  16. Kim MJ, Moon Y, Tou JC, Mou B, Waterland NL. Nutritional value, bioactive compounds and health benefits of lettuce (Lactuca sativa L.). J Food Composition Anal. 2016;49:19-34.
  17. Housey GM, Balash M. Plant Extracts with Anti-Diabetic and Other Useful Activities. Republic of South Africa Patent No. 2015/07368 Filed March 12, 2014. Issued January 31, 2018.
  18. Froushani SMA, Zarei L, Ghaleh HEG, Motlagh BM. Estragole and methyl-eugenol-free extract of Artemisia dracunculus possesses immunomodulatory effects. Avicenna J Phytomedicine. 2015;6(5):526-534
  19. Zhang J-M, An J. Cytokines, inflammation, and pain. Int Anesthesiol Clin. 2007;45:27-37
  20. Chromium Dietary Supplement Fact Sheet. National Institutes of Health. Office of Dietary Supplements. 2019. Available at: https://ods.od.nih.gov/ factsheets/Chromium-HealthProfessional/#h4. Accessed November 1, 2019.
  21. The risk of inactive ingredients in everyday drugs. Harvard Health Letter. Harvard Health Publishing. Published July 2019.  Available at: https://www.health.harvard.edu/staying-healthy/the-risk-of-inactive-ingredients-in-everyday-drugs. Accessed November 1, 2019.